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Article

Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2002

Nithiyananthan Ratnasingam, Heward Joanne M, Allahabadia Amit, Franklyn Jayne A, Gough Stephen C L

Abstract excerpt

The cytotoxic T-lymphocyte-associated-4 (CTLA-4) molecule plays an important role in immune regulation by downregulating activation of T cells by antigen-presenting cells. Polymorphisms of the CTLA-4 gene have been shown to be associated with susceptibility to a number of autoimmune diseases. Some, but not all, studies suggest association between the CTLA-4 gene and autoimmune hypothyroidism. The aim of this...

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Identifiers

PMID: 11842815
DOI: 10.1089/105072502753451896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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