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Article

Selection of CD4+CD8+ thymocytes by complex formation with medulla-derived epithelial cells.

Cellular immunology - 1 Mar 1990

Hugo P, Potworowski E F

Abstract excerpt

The role of lymphostromal complexes in T-cell differentiation is far from elucidated, mainly because a clear association of a particular stromal cell type with a distinct thymocyte subset has never been identified. Using an in vitro system, detecting the adherence of thymocytes to a thymic medullary epithelial cell line (E-5), we showed that the phenotype of these thymocytes was that of cortical type: Thy-1hi,...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
CD4 Antigens
CD8 Antigens
Cell Adhesion
Epithelium
Interphase
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Phenotype
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thymus Gland

Source

Identifiers

PMID: 2105850
DOI: 10.1016/0008-8749(90)90307-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2105850-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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