Article
In vitro negative selection of alpha beta T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells.
European journal of immunology - 1 Oct 1993
Tanaka Y, Mamalaki C, Stockinger B, Kioussis D
Abstract excerpt
We have established conditionally immortalized thymic cortical epithelial cell lines from transgenic mice carrying a temperature-sensitive SV40 large T antigen. One of these cell lines expresses cortical markers and produces IL-1 alpha, IL-6, IL-7, and TGF-beta 1. These cells express class I majo...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- Cell Division
- Cell Line
- Cytokines
- DNA Primers
- Dendritic Cells
- Down-Regulation
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Cell Surface