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Article

Engineering gene expression and protein synthesis by modulation of nuclear shape.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Thomas Carson H, Collier Joel H, Sfeir Charles S, Healy Kevin E

Abstract excerpt

The current understanding of the relationships between cell shape, intracellular forces and signaling, nuclear shape and organization, and gene expression is in its infancy. Here we introduce a method for investigating gene-specific responses in individual cells with controlled nuclear shape and projected area. The shape of the nuclei of primary osteogenic cells were controlled on microfabricated substrata with...

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Identifiers

PMID: 11842191
DOI: 10.1073/pnas.032668799
PMCID: PMC122304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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