Article
On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells.
Scientific reports - 4 Nov 2020
Vasilevich Aliaksei S, Vermeulen Steven, Kamphuis Marloes, Roumans Nadia, Eroumé Said, Hebels Dennie G A J, van de Peppel Jeroen, Reihs Rika, Beijer Nick R M, Carlier Aurélie, Carpenter Anne E, Singh Shantanu, de Boer Jan
Abstract excerpt
Learning rules by which cell shape impacts cell function would enable control of cell physiology and fate in medical applications, particularly, on the interface of cells and material of the implants. We defined the phenotypic response of human bone marrow-derived mesenchymal stem cells (hMSCs) to 2176 randomly generated surface topographies by probing basic functions such as migration, proliferation, protein...
Topics
- Adipogenesis
- Cell Culture Techniques
- Cell Differentiation
- Cell Proliferation
- Cell Shape
- Cells, Cultured
- Gene Expression Profiling
- High-Throughput Nucleotide Sequencing
- Humans