Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C1188D mutation abolishes specific recognition between MLL1-CXXC domain and CpG site by inducing conformational switch of flexible N-terminal.

Proteins - 1 Nov 2020

Chen Jiawen, Qi Yanping, Duan Yong, Duan Mojie, Yang Minghui

Abstract excerpt

Mixed lineage leukemia protein (MLL1 protein) recognizes the CpG site via its CXXC domain and is frequently associated with leukemia. The specific recognition is abolished by C1188D mutation, which also prevents MLL-related leukemia. In this paper, multiple molecular dynamic (MD) simulations were performed to investigate the mechanism of recognition and influences of C1188D mutation. Started from fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to CpG Islands
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid-Lymphoid Leukemia Protein

Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Protein Interaction Domains and Motifs

Share to Static Electricity

Source

Identifiers

PMID: 32519403
DOI: 10.1002/prot.25960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C1188D mutation abolishes specific recognition between MLL1-CXXC domain and CpG site by inducing conformational switch of flexible N-terminal.PMID 32519403Read ↗

Role of DNA conformation & energetic insights in Msx-1-DNA recognition as revealed by molecular dynamics studies on specific and nonspecific complexes.Semantic proximity Read ↗

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.Semantic proximity Read ↗

Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.Semantic proximity Read ↗

Double GC:GC mismatch in dsDNA enhances local dynamics retaining the DNA footprint: a high-resolution NMR study.Semantic proximity Read ↗

Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies.Semantic proximity Read ↗

A novel approach of dynamic cross correlation analysis on molecular dynamics simulations and its application to Ets1 dimer-DNA complex.Semantic proximity Read ↗

Molecular basis of facilitated target search and sequence discrimination of TALE homeodomain transcription factor Meis1.Semantic proximity Read ↗

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylationSemantic proximity Read ↗

Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences.Semantic proximity Read ↗

Dynamic features of carboxy cytoglobin distal mutants investigated by molecular dynamics simulations.Semantic proximity Read ↗

Conformational dynamics is critical for the allosteric inhibition of cGAS upon acetyl-mimic mutations.Semantic proximity Read ↗

Exploring the potential of complex formation between a mutant DNA and the wild type protein counterpart: a MM and MD simulation approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.