Article

Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq

2023-10-05

Abstract excerpt

Telomerase is a specialized reverse transcriptase that uses an intrinsic RNA subunit as the template for telomeric DNA synthesis. Biogenesis of human telomerase requires its RNA subunit (hTR) to fold into a multi-domain architecture that includes the template-containing pseudoknot (t/PK) and the three-way junction (CR4/5). These two hTR domains bind the telomerase reverse transcriptase (hTERT) protein and are thus...

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Literature Corpus work: 36a9bc8a-3816-5cab-a194-6947b396685c
DOI: 10.1101/2023.10.04.560962

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