Toward the therapeutic editing of mutated RNA sequences.

doi:10.1073/pnas.92.18.8298

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Article

Toward the therapeutic editing of mutated RNA sequences.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Woolf T M, Chase J M, Stinchcomb D T

Abstract excerpt

If RNA editing could be rationally directed to mutated RNA sequences, genetic diseases caused by certain base substitutions could be treated. Here we use a synthetic complementary RNA oligonucleotide to direct the correction of a premature stop codon mutation in dystrophin RNA. The complementary...

Topics

Adenosine Deaminase
Animals
Base Sequence
Codon, Terminator
Dystrophin
Genetic Therapy
Humans
Molecular Sequence Data
Mutation
RNA
RNA Editing
Xenopus

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