Article
Toward the therapeutic editing of mutated RNA sequences.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995
Woolf T M, Chase J M, Stinchcomb D T
Abstract excerpt
If RNA editing could be rationally directed to mutated RNA sequences, genetic diseases caused by certain base substitutions could be treated. Here we use a synthetic complementary RNA oligonucleotide to direct the correction of a premature stop codon mutation in dystrophin RNA. The complementary RNA oligonucleotide was hybridized to a premature stop codon and the hybrid was treated with nuclear extracts...
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