Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes.

The Journal of investigative dermatology - 1 Feb 2002

van der Gaag Ellen J, Leccia Marie-Thérèse, Dekker Sybren K, Jalbert Nicole L, Amodeo Dana M, Byers H Randolph

Abstract excerpt

Cell spreading, proliferation, and survival are modulated by focal adhesions linking extracellular matrix proteins, integrins, and the cytoskeleton. Zyxin is a focal-adhesion-associated phosphoprotein with one domain involved in the control of actin assembly and three protein-protein adapter domains implicated in the regulation of cell growth and differentiation. We characterized zyxin expression in normal human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Focal Adhesion Kinase 1
Share to Focal Adhesion Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoproteins

Share to Melanocytes

Share to Metalloproteins

Share to Paxillin

Share to Protein-Tyrosine Kinases

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 11841540
DOI: 10.1046/j.0022-202x.2001.01657.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes.PMID 11841540Read ↗

Phosphorylation of actopaxin regulates cell spreading and migration.Semantic proximity Read ↗

Molecular Characterization of Human ZyxinSemantic proximity Read ↗

Zyxin: a mechanotransductor to regulate gene expression.Semantic proximity Read ↗

Enhancement of Zyxin Promotes Skin Fibrosis by Regulating FAK/PI3K/AKT and TGF-β Signaling Pathways via IntegrinsSemantic proximity Read ↗

Mechanisms Contributing to Differential Regulation of PAX3 Downstream Target Genes in Normal Human Epidermal Melanocytes versus Melanoma CellsSemantic proximity Read ↗

Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.Semantic proximity Read ↗

Thymosin β4 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and InvasionSemantic proximity Read ↗

Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions.Semantic proximity Read ↗

Beta-catenin in the melanocyte lineage.Semantic proximity Read ↗

Loss of EphB6 expression in metastatic melanomaSemantic proximity Read ↗

Differential roles of gangliosides in malignant properties of melanomasSemantic proximity Read ↗

Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.