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Article

Loss of EphB6 expression in metastatic melanoma

1 Dec 2003

Abstract excerpt

Overexpression of various members of the Eph receptor tyrosine kinases and their ephrin ligands has been frequently reported in cancer. In contrast, a loss of EphB6 gene expression has been correlated with a poor prognosis in human neuroblastoma, suggesting a distinct role for this receptor compared to other family members. More recently, an important role of EphB6 signalling in T-cells has been described,...

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PMID: 14612926
DOI: 10.3892/ijo.23.6.1553

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