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Article

Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.

Biochimica et biophysica acta - 1 Mar 2008

Hamamura Kazunori, Tsuji Momoko, Ohkawa Yuki, Nakashima Hideyuki, Miyazaki Sayaka, Urano Takeshi, Yamamoto Noriyuki, Ueda Minoru, Furukawa Koichi, Furukawa Keiko

Abstract excerpt

Mass spectrometry analysis of immunoprecipitates from serum-treated GD3-expressing melanoma cells with PY20 (anti-phosphotyrosine antibody) revealed that focal adhesion kinase (FAK) is more strongly activated in GD3-expressing cells than in GD3-negative cells. Involvement of FAK in the increased proliferation and invasion in GD3-expressing melanomas was demonstrated by siRNA-mediated knockdown. Also, it was shown...

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Identifiers

PMID: 18078823
DOI: 10.1016/j.bbagen.2007.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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