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[In vitro molecular evolution of humanized mouse ScFv specific against human cross-linked fibrin].

Yi chuan xue bao = Acta genetica Sinica - 1 Jan 2002

Liu Zhi-Gang, Yu Wei-Yuan, Lin Jian-Bo

Abstract excerpt

In early work at our laboratory, a mouse ScFv All specific against human cross-linked fibrin was picked out by using phage displaying technique, and it was useful in prepareing targeting thrombolytic agent. To reduce its immunogenicity, All was humanized according to the surface reshaping approach. In order to increase the affinity and specifity of humanized ScFv, the Mixed HCDR3 and LCDR3 library was constructed...

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Identifiers

PMID: 11838383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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