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Article

[Mutational analysis of platelet fibrinogen receptor ligand binding domain].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Mar 1994

Shimomura T, Fujimura K

Abstract excerpt

Platelet glycoprotein (GP) IIb-IIIa (alpha IIb beta 3) binds fibrinogen with high affinity. To identify structure responsible for the alpha IIb beta 3 specific fibrinogen binding, chimeric receptors between alpha IIb and alpha v were constructed, expressed on heterologous cells, and their function was analyzed. Chimeric receptors with mutations in calcium binding sequences showed similar ligand specificity as...

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PMID: 7512669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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