[Mutational analysis of platelet fibrinogen receptor ligand binding domain].

Article

[Mutational analysis of platelet fibrinogen receptor ligand binding domain].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Mar 1994

Shimomura T, Fujimura K

Abstract excerpt

Platelet glycoprotein (GP) IIb-IIIa (alpha IIb beta 3) binds fibrinogen with high affinity. To identify structure responsible for the alpha IIb beta 3 specific fibrinogen binding, chimeric receptors between alpha IIb and alpha v were constructed, expressed on heterologous cells, and their functio...

Topics

Animals
Blood Platelets
CHO Cells
Cricetinae
DNA Mutational Analysis
Fibrinogen
Integrins
Ligands
Mice
Mutation
Platelet Membrane Glycoproteins
Receptors, Cytoadhesin
Receptors, Vitronectin

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