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Article

A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries

21 Jul 1998

Abstract excerpt

The development of a new strategy for antibody humanization is described. This strategy incorporates key recognition sequences from the parental rodent antibody into a phage display-based selection strategy. The original sequences of the third complementarity-determining regions (CDRs) of heavy and light chains, HCDR3 and LCDR3, were maintained and all other sequences were replaced by human sequences selected...

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Identifiers

PMID: 9671778
DOI: 10.1073/pnas.95.15.8910

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