Article
[The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Oct 2008
Li Chanyuan, Wang Shuyun, Yuan Haiming, Li Wei, Li Zizheng, Li Xiaoyu, Guo Xing, Li Fucai
Abstract excerpt
OBJECTIVE: To investigate the association of mutations and expression of MUS81 gene with the tumorigenesis and progression of laryngeal squamous cell carcinoma (LSCC). METHODS: PCR-SSCP and DNA sequencing were carried out to examine mutations at exons 9 and 10 of MUS81 gene in 42 LSCC samples, with paired adjacent normal laryngeal tissues (PANLs) as control. Semi-quantitative RT-PCR and Western blot were used to...
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