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Article

Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant.

The Journal of biological chemistry - 19 Apr 2002

Yang Edward, Henriksen Melissa A, Schaefer Olaf, Zakharova Natalia, Darnell James E

Abstract excerpt

The STAT1 transcription factor is organized into several highly conserved domains, each of which has been assigned a function with the exception of the linker domain. We previously characterized a mutant in the linker domain of STAT1 that gave normal DNA binding using a standard probe in an electrophoretic mobility assay but failed to activate transcription in response to interferon gamma. We now report the...

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Identifiers

PMID: 11834743
DOI: 10.1074/jbc.M112038200

Genes

STAT1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dissociation time from DNA determines transcriptional function in a STAT1 linker mutant.PMID 11834743Read ↗

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