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Article

DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1.

Genes & development - 15 Aug 2003

Meyer Thomas, Marg Andreas, Lemke Petra, Wiesner Burkhard, Vinkemeier Uwe

Abstract excerpt

Cytokine-dependent gene transcription greatly depends on the tyrosine phosphorylation ("activation") of Stat proteins at the cell membrane. This rapidly leads to their accumulation in the nucleus by an unknown mechanism. We performed microinjections of recombinant Stat1 protein to show that nuclear accumulation of phosphorylated Stat1 can occur without cytokine stimulation of cells. Microinjection of Stat1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12923054
DOI: 10.1101/gad.268003
PMCID: PMC196254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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