Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A.

The Journal of biological chemistry - 13 May 2005

Vellaichamy Elangovan, Khurana Madan L, Fink Jude, Pandey Kailash N

Abstract excerpt

Mice carrying a targeted disruption of the Npr1 gene (coding for guanylyl cyclase/natriuretic peptide receptor A (NPRA)) exhibit increased blood pressure, cardiac hypertrophy, and congestive heart failure, similar to untreated human hypertensive patients. The objective of this study was to determine whether permanent ablation of NPRA signaling in mice alters the expression of matrix metalloproteinase (MMP)-2 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antihypertensive Agents
Share to Cyclic GMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Densitometry

Share to Guanylate Cyclase

Share to Hydroxyproline

Share to I-kappa B Kinase

Share to Matrix Metalloproteinase 2

Share to Receptors, Atrial Natriuretic Factor

Source

Identifiers

PMID: 15710627
DOI: 10.1074/jbc.M411373200

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A.PMID 15710627Read ↗

Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart.Semantic proximity Read ↗

Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload.Semantic proximity Read ↗

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis.Semantic proximity Read ↗

Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathySemantic proximity Read ↗

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis.Semantic proximity Read ↗

Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death.Semantic proximity Read ↗

Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice.Semantic proximity Read ↗

The orphan nuclear receptor Nr4a1 contributes to interstitial cardiac fibrosis via modulation of cardiac fibroblast and macrophage phenotype.Semantic proximity Read ↗

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.Semantic proximity Read ↗

Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overloadSemantic proximity Read ↗

The Orphan Nuclear Receptor Nr4a1 Contributes to Interstitial Cardiac Fibrosis via Modulation of Cardiac Fibroblast and Macrophage PhenotypeSemantic proximity Read ↗

MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.