Article
Transcriptional regulation of the type I myosin heavy chain promoter in inactive rat soleus.
American journal of physiology. Cell physiology - 1 Mar 2002
Huey K A, Roy R R, Haddad Fadia, Edgerton V R, Baldwin Kenneth M
Abstract excerpt
Chronic muscle inactivity with spinal cord isolation (SI) decreases expression of slow type I myosin heavy chain (MHC) while increasing expression of the faster MHC isoforms, primarily IIx. The purpose of this study was to determine whether type I MHC downregulation in the soleus muscle of SI rats is regulated transcriptionally and to identify cis-acting elements or regions of the rat type I MHC gene promoter...
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