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Article

Assessment of the frequency of allelic imbalance in human tissue using a multiplex polymerase chain reaction system.

The Journal of molecular diagnostics : JMD - 1 Apr 2007

Heaphy Christopher M, Hines William C, Butler Kimberly S, Haaland Christina M, Heywood Glenroy, Fischer Edgar G, Bisoffi Marco, Griffith Jeffrey K

Abstract excerpt

Genomic instability can generate chromosome breakage and fusion randomly throughout the genome, frequently resulting in allelic imbalance, a deviation from the normal 1:1 ratio of maternal and paternal alleles. Allelic imbalance reflects the karyotypic complexity of the cancer genome. Therefore, it is reasonable to speculate that tissues with more sites of allelic imbalance have a greater likelihood of having...

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Identifiers

PMID: 17384220
DOI: 10.2353/jmoldx.2007.060115
PMCID: PMC1867446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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