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Article

Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53.

Cancer research - 1 Feb 2002

Angelo Laura S, Talpaz Moshe, Kurzrock Razelle

Abstract excerpt

Interleukin (IL)-6 is an autocrine growth factor for renal cell carcinoma (RCC). We sought to determine whether p53 regulates constitutive IL-6 production. RCC cell lines containing mutant (mut) p53 produced higher levels of IL-6 than those containing wild-type (wt) p53 (P < 0.05). Transfection of wt p53 into RCC cell lines bearing mut p53 (UOK 121LN) or wt p53 (A498 and ACHN) resulted in repression of IL-6...

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Share to Carcinoma, Renal Cell
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PMID: 11830554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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