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Article

Constitutive IL-8 expression in cancer cells is associated with mutation of p53.

Journal of experimental & clinical cancer research : CR - 1 Mar 2005

Hidaka H, Ishiko T, Ishikawa S, Ikeda O, Mita S, Iwamura T, Chijiiwa K, Ogawa M

Abstract excerpt

We previously reported that most cancer cell lines constitutively express various cytokines including IL-8. But how IL-8 gene expression is regulated in cancer cells is still unclear. p53 tumor suppressor gene plays an important role in the regulation of transcription and is mutated in cancer cell lines. We investigated whether p53 status affects the constitutive expression of IL-8 in human cancer cells. SUIT-2...

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PMID: 15945132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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