Article
A highly informative SNP linkage panel for human genetic studies.
Nature methods - 1 Nov 2004
Murray Sarah Shaw, Oliphant Arnold, Shen Richard, McBride Celeste, Steeke Rhoberta J, Shannon Stuart G, Rubano Todd, Kermani Bahram G, Fan Jian-Bing, Chee Mark S, Hansen Mark S T
Abstract excerpt
We have developed a highly informative set of single-nucleotide polymorphism (SNP) assays designed for linkage mapping of the human genome. These assays were developed on a robust multiplexed assay system to provide a combination of very high accuracy and data completeness with high throughput for linkage studies. The linkage panel is comprised of approximately 4,700 SNPs with 0.39 average minor allele frequency...
Topics
- Algorithms
- Chromosome Mapping
- DNA Mutational Analysis
- Genetic Testing
- Genome, Human
- Genotype
- Humans
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- Reproducibility of Results
- Sensitivity and Specificity
- Sequence Alignment