Article
Linkage disequilibrium and haplotype homozygosity in population samples genotyped at a high marker density.
Human heredity - 1 Jan 2006
Wang Hui, Lin Chia-Ho, Service Susan, Chen Yuguo, Freimer Nelson, Sabatti Chiara
Abstract excerpt
OBJECTIVE: Analyze the information contained in homozygous haplotypes detected with high density genotyping. METHODS: We analyze the genotypes of approximately 2,500 markers on chr 22 in 12 population samples, each including 200 individuals. We develop a measure of disequilibrium based on haplotype homozygosity and an algorithm to identify genomic segments characterized by non-random homozygosity (NRH), taking...
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