Article
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda).
Microbes and infection - 1 Jan 2002
Hoerauf Achim, Kruse Susanne, Brattig Norbert W, Heinzmann Andrea, Mueller-Myhsok Bertram, Deichmann Klaus A
Abstract excerpt
Onchocerca volvulus infection usually results in a predominantly immunopermissive reaction called generalized onchocerciasis and characterized by high microfilarial burden and immunological tolerance to the worms. Rarely, however, infection leads to the sowda form of the disease displaying low microfilarial numbers, i.e. microfilarial control, and a T helper 2 (Th2)-type immune response including high...
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