Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T Cells

8 Jan 2015

Abstract excerpt

Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 responses could be related to aggravated pathology in HO. Using flow cytometry, filarial-specific cytokine responses and PCR arrays, we compared the immune cell profiles,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasite Biology and Host Interactions
Share to Parasites and Host Interactions
Share to Parasitic Diseases Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25569210
DOI: 10.1371/journal.pntd.0003414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T CellsPMID 25569210Read ↗

The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda).Semantic proximity Read ↗

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective responseSemantic proximity Read ↗

T follicular helper cells differentiate from Th2 cells in response to helminth antigensSemantic proximity Read ↗

Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen.Semantic proximity Read ↗

T-cell regulation in helminth parasite infections: implications for inflammatory diseases.Semantic proximity Read ↗

The Role of Th17/Treg Dynamics in Dengue and Lassa fever Infections in West Africa Sub-RegionSemantic proximity Read ↗

Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteomeSemantic proximity Read ↗

Functionally distinct T-helper cell phenotypes predict resistance to different types of parasites in a wild mammal.Semantic proximity Read ↗

Th17/Treg imbalance in patients with liver cystic echinococcosisSemantic proximity Read ↗

Chronic Helminth Infection Promotes Immune Regulation In Vivo through Dominance of CD11cloCD103− Dendritic CellsSemantic proximity Read ↗

Mucosal Expression of T Cell Gene Variants Is Associated with Differential Resistance to Teladorsagia circumcincta.Semantic proximity Read ↗

Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.