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Article

Decreased capacity for debrisoquine metabolism among black Tanzanians: analyses of the CYP2D6 genotype and phenotype.

Pharmacogenetics - 1 Dec 1999

Wennerholm A, Johansson I, Massele A Y, Lande M, Alm C, Aden-Abdi Y, Dahl M L, Ingelman-Sundberg M, Bertilsson L, Gustafsson L L

Abstract excerpt

The cytochrome P450 2D6 (CYP2D6) genotypes and phenotypes of 106 unrelated, healthy black Tanzanians of Bantu origin were investigated. The results revealed a population with a generally decreased capacity to metabolize the CYP2D6 substrate debrisoquine with 59% of the Tanzanian extensive metabolisers having debrisoquine metabolic ratios (MRs) > 1 versus 20% in Caucasians. This decrease in metabolic capacity was...

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PMID: 10634133

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