[Genetic polymorphism of enzymes metabolizing xenobiotics as a factor in susceptibility to tumor development].

Abstract excerpt

Organisms are exposed to a large number of xenobiotics (compounds foreign to the body), such as drugs, pesticides, natural food constituents and so on. To deal with these, usually lipophilic substances, a range of biotransformation enzyme systems are available. Experimental data have shown that metabolic activation and detoxification play an important role in chemical carcinogenesis. There is a considerable...

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