Article
Formation of functional synaptic connections between cultured cortical neurons from agrin-deficient mice.
Journal of neurobiology - 15 Jun 1999
Li Z, Hilgenberg L G, O'Dowd D K, Smith M A
Abstract excerpt
Numerous studies suggest that the extracellular matrix protein agrin directs the formation of the postsynaptic apparatus at the neuromuscular junction (NMJ). Strong support for this hypothesis comes from the observation that the high density of acetylcholine receptors (AChR) normally present at the neuromuscular junction fails to form in muscle of embryonic agrin mutant mice. Agrin is expressed by many...
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