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Article

Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells.

Gene - 9 Jan 2002

Kobayashi Kazuyasu, Ouchida Mamoru, Tsuji Toshiya, Hanafusa Hiroko, Miyazaki Masahiro, Namba Masayoshi, Shimizu Nobuyoshi, Shimizu Kenji

Abstract excerpt

The human REIC gene is a recently found mortalization-related gene and a candidate tumor suppressor gene expression of which is largely attenuated in many immortalized and tumor-derived cell lines (Biochem. Biophys. Res. Commun. 268 (2000) 20-24). To gain insight into the mechanisms of the down-regulation, we investigated the genomic structure and promoter activity of the human REIC gene. The gene, identical with...

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PMID: 11814687
DOI: 10.1016/s0378-1119(01)00838-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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