Article
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Cancer science - 1 Feb 2007
Chang Huang-Chou, Cho Chun-Yu, Hung Wen-Chun
Abstract excerpt
In the present study, we addressed the molecular mechanism of the downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK), a critical tumor suppressor that can potently inhibit angiogenesis and metastasis, in non-small cell lung cancer and its clinical significance. The methylation status of the RECK gene promoter was studied by methylation-specific polymerase chain reaction. RECK mRNA...
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