Article
Detection of single nucleotide substitution by competitive allele-specific short oligonucleotide hybridization (CASSOH) with immunochromatographic strip.
Human mutation - 1 Aug 2003
Matsubara Yoichi, Kure Shigeo
Abstract excerpt
Recent advances in human genome research have revealed that genetic polymorphisms, such as single nucleotide polymorphisms (SNPs), are closely associated with susceptibility to various common diseases and adverse drug reactions. Also, numerous mutations responsible for a number of genetic diseases have been identified. Clinical application of genetic information to individual health care requires simple and rapid...
Topics
- Alleles
- Binding, Competitive
- Chromatography
- DNA
- False Positive Reactions
- Feasibility Studies
- Genotype
- Humans
- Immunoassay
- Mutagenesis, Insertional
- Nucleic Acid Hybridization
- Nucleotides
- Oligonucleotide Probes
- Oligonucleotides
- Point Mutation