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Article

A second NAD(+)-dependent DNA ligase (LigB) in Escherichia coli.

Nucleic acids research - 15 Dec 2001

Sriskanda V, Shuman S

Abstract excerpt

Escherichia coli DNA ligase (LigA) is the prototype of the NAD(+)-dependent class of DNA ligases found in all bacteria. Here we report the characterization of E.coli LigB, a second NAD(+)-dependent DNA ligase identified by virtue of its sequence similarity to LigA. LigB differs from LigA in that it lacks the BRCA1 C-terminus domain (BRCT) and two of the four Zn-binding cysteines that are present in LigA and all...

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Source

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Identifiers

PMID: 11812821
DOI: 10.1093/nar/29.24.4930
PMCID: PMC97608

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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