A second NAD(+)-dependent DNA ligase (LigB) in Escherichia coli.

doi:10.1093/nar/29.24.4930

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A second NAD(+)-dependent DNA ligase (LigB) in Escherichia coli.

Nucleic acids research - 15 Dec 2001

Sriskanda V, Shuman S

Abstract excerpt

Escherichia coli DNA ligase (LigA) is the prototype of the NAD(+)-dependent class of DNA ligases found in all bacteria. Here we report the characterization of E.coli LigB, a second NAD(+)-dependent DNA ligase identified by virtue of its sequence similarity to LigA. LigB differs from LigA in that it lacks the BRCA1 C-terminus domain (BRCT) and two of the four Zn-binding cysteines that are present in LigA and all...

Topics

Alanine
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
DNA Ligases
DNA, Bacterial
Escherichia coli
Isoenzymes
Lysine
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 11812821
DOI: 10.1093/nar/29.24.4930
PMCID: PMC97608

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics