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Article

Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+.

The Journal of biological chemistry - 22 Mar 2002

Sriskanda Verl, Shuman Stewart

Abstract excerpt

NAD(+)-dependent DNA ligases are present in all bacteria and are essential for growth. Their unique substrate specificity compared with ATP-dependent human DNA ligases recommends the NAD(+) ligases as targets for the development of new broad-spectrum antibiotics. A plausible strategy for drug discovery is to identify the structural components of bacterial DNA ligase that interact with NAD(+) and then to isolate...

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PMID: 11781321
DOI: 10.1074/jbc.M111164200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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