Significance of genetic variation at the glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase 1 detoxification genes in breast cancer development.

doi:10.1159/000048245

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Article

Significance of genetic variation at the glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase 1 detoxification genes in breast cancer development.

Oncology - 1 Jan 2002

Siegelmann-Danieli Nava, Buetow Kenneth H

Abstract excerpt

This work examined the role of constitutional genetic variation at the glutathione S-transferase M1 (GSTM1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) detoxification loci in breast cancer development. Methods included contrasting patterns of genetic variations at these loci between cases with breast cancer and healthy controls and assessing the association of genotypes with tumor characteristics. Participants...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Breast Neoplasms
Female
Gene Frequency
Genetic Variation
Genotype
Glutathione Transferase
Humans
Middle Aged
Mutation
Neoplasm Staging
Philadelphia
Quinone Reductases
White People

Source

Open in PubMed

Identifiers

PMID: 11810042
DOI: 10.1159/000048245

Genes

GSTM1
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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