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Article

Effects of GSTT1 and GSTM1 polymorphisms in glutathione levels and breast cancer development in Brazilian patients.

Molecular biology reports - 1 Jan 2021

Pacholak Letícia Madureira, Kern Rodrigo, de Oliveira Stefania Tagliari, Lúcio Leia Carolina, Amarante Marla Karine, Guembarovski Roberta Losi, Watanabe Maria Angélica Ehara, Panis Carolina

Abstract excerpt

Polymorphisms in the glutathione transferase enzymes (GSTs) genes have been associated with susceptibility to develop breast cancer (BC), but few are known regarding its role on this disease prognosis and impact on antioxidant status. This study evaluated the polymorphisms of GSTM1 and GSTT1 genes and their relationship with BC susceptibility and prognostic, as well as its impact on plasma reduced glutathione...

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PMID: 33452993
DOI: 10.1007/s11033-020-06107-w

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