Article
Factors associated with oxidative stress and cancer risk in the Breast and Prostate Cancer Cohort Consortium.
Free radical research - 1 Mar 2014
Blein S, Berndt S, Joshi A D, Campa D, Ziegler R G, Riboli E, Cox D G
Abstract excerpt
Both endogenous factors (genomic variations) and exogenous factors (environmental exposures, lifestyle) impact the balance of reactive oxygen species (ROS). Variants of the ND3 (rs2853826; G10398A) gene of the mitochondrial genome, manganese superoxide dismutase (MnSOD; rs4880 Val16Ala) and glutathione peroxidase (GPX-1; rs1050450 Pro198Leu), are purported to have functional effects on regulation of ROS balance....
Topics
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
