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Article

Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy

1 Jan 2002

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a small conductance chloride ion channel that may interact directly with other channels including the epithelial sodium channel (ENaC). CFTR is known to be more abundant in the airway epithelium during the second trimester of human development than after birth. This could be a consequence of the change in function of the respiratory...

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PMID: 11809721
DOI: 10.1093/hmg/11.2.125

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