Article
Developmental dynamics of ovine lung in health and cystic fibrosis at single-cell resolution.
Functional & integrative genomics - 31 Jul 2026
Tkachenko Svyatoslav, Leir Shih-Hsing, Van Wettere Arnaud J, Perisse Iuri Viotti, Mustafa Yasmin, Marriott Cheyenne M, Patrick Tayler, Liu Ying, White Kenneth L, Polejaeva Irina A, Harris Ann
Abstract excerpt
The sheep lung has long been used to model aspects of the human lung, both its normal development and pathological changes that occur in ovine models of lung disease. The similarities between the two species provide an opportunity to investigate phases of lung development that are not accessible for investigation in humans, for example later in gestation. Here we use single cell (sc) RNA-seq to investigate the...
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