Article
Transcription factors and miRNAs that regulate fetal to adult CFTR expression change are new targets for cystic fibrosis.
The European respiratory journal - 1 Jan 2015
Viart Victoria, Bergougnoux Anne, Bonini Jennifer, Varilh Jessica, Chiron Raphaël, Tabary Olivier, Molinari Nicolas, Claustres Mireille, Taulan-Cadars Magali
Abstract excerpt
The CFTR gene displays a tightly regulated tissue-specific and temporal expression. Mutations in this gene cause cystic fibrosis (CF). In this study we wanted to identify trans-regulatory elements responsible for CFTR differential expression in fetal and adult lung, and to determine the importanc...
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