Cellular imbalance in proximal and distal lung of CFTR−/− sheep in utero and at birth

Abstract excerpt

Abstract Background The Lung is the major focus of therapeutic approaches for the inherited disorder cystic fibrosis (CF) as without treatment lung disease is life-limiting. However, the initiating events that predispose the CF lung to cycles of infection, inflammation and resultant tissue damage are still unclear. Inflammation may occur in the CF lung prior to birth in human and several large animal models...

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