Article
Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma.
Cancer letters - 25 Feb 2002
Hanafusa Tadashi, Yumoto Yasuhiro, Nouso Kazuhiro, Nakatsukasa Harushige, Onishi Toru, Fujikawa Tatsuya, Taniyama Mayumi, Nakamura Shinichiro, Uemura Masayuki, Takuma Yoshitaka, Yumoto Eiichiro, Higashi Toshihiro, Tsuji Takao
Abstract excerpt
Insulin-like growth factor binding protein-3 (IGFBP-3) is postulated to be a mediator of growth suppression signals. Reduced expression of the IGFBP-3 was observed in nine out of 12 human hepatocellular carcinomas (HCC) (75%). Promoter hypermethylation of the IGFBP-3 was detected in four out of 12 HCCs (33%) although mutations were not identified. The expression of IGFBP-3 was restored by the demethylating agent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.