Article
Distribution of lod scores in oligogenic linkage analysis.
Genetic epidemiology - 1 Jan 2001
Williams J T, North K E, Martin L J, Comuzzie A G, Göring H H, Blangero J
Abstract excerpt
In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the ith quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oligogenic linkage analysis with the empirical lod score distribution under a null model...
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