Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variance components analysis for genetic linkage of time to onset for disease.

Genetic epidemiology - 1 Jan 2001

Amos C I, Shete S, Gu X

Abstract excerpt

We compared two variance components methods for detecting genes that influence time to onset for a complex disease using simulated data. We first divided the extended families into nuclear families. The first method fitted variance components to the martingale residuals, which were obtained from first fitting a proportional hazards model to the time to onset data for the trait, allowing for the quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Chromosomes, Human, Pair 6
Share to Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Lod Score

Share to Proportional Hazards Models

Share to Quantitative Trait, Heritable

Share to Survival Analysis

Source

Identifiers

PMID: 11793775
DOI: 10.1002/gepi.2001.21.s1.s768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variance components analysis for genetic linkage of time to onset for disease.PMID 11793775Read ↗

Practical application of residuals from survival models in quantitative trait linkage analysis.Semantic proximity Read ↗

Association and linkage for age at onset of a common oligogenic disease using genetic variance component models.Semantic proximity Read ↗

Variance components analysis for pedigree-based censored survival data using generalized linear mixed models (GLMMs) and Gibbs sampling in BUGS.Semantic proximity Read ↗

Linkage analysis for diseases with variable age of onset.Semantic proximity Read ↗

The additive genetic gamma frailty model for linkage analysis of age-of-onset variation.Semantic proximity Read ↗

An additive genetic gamma frailty model for linkage analysis of diseases with variable age of onset using nuclear families.Semantic proximity Read ↗

A general test of association for complex diseases with variable age of onset.Semantic proximity Read ↗

Case-sibling gene-association studies for diseases with variable age at onset.Semantic proximity Read ↗

The analysis of survival data with a non-susceptible fraction and dual censoring mechanisms.Semantic proximity Read ↗

Family-based association test method: age of onset traits and covariates.Semantic proximity Read ↗

Effects of age at onset on the power of the affected sib pair and transmission/disequilibrium tests.Semantic proximity Read ↗

Extensions to sib-pair linkage tests applicable to disorders characterized by delayed onset.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.