Article
Comparison of marker intervals and number of sib pairs used for linkage analysis on simulated nuclear family data.
Genetic epidemiology - 1 Jan 2001
Cheng R, Ma J Z, Elston R C, Li M D
Abstract excerpt
Using a two-stage global scan design, we analyzed general population replicates 1 and 42 of the Genetic Analysis Workshop (GAW) 12 simulated data set using three methods: revisited Haseman-Elston (HER), maximum likelihood variance estimation (ML), and variance components (VC). Three marker densities, 5-, 10-, and 15-cM intervals, were examined in the first-stage scan. We found that the 10-cM interval appears to...
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