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Article

Formation of Polyglutamine Inclusions in Non-CNS Tissue

1 May 1999

Abstract excerpt

Huntington's disease (HD) is one of a class of inherited progressive neurodegenerative disorders that are caused by a CAG/polyglutamine repeat expansion. We have previously generated mice that are transgenic for exon 1 of the HD gene carrying highly expanded CAG repeats which develop a progressive movement disorder and weight loss with similarities to HD. Neuronal inclusions composed of the exon 1 protein and...

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PMID: 10196370
DOI: 10.1093/hmg/8.5.813

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