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Article

Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model.

The American journal of pathology - 1 Dec 2008

von Köckritz-Blickwede Maren, Rohde Manfred, Oehmcke Sonja, Miller Lloyd S, Cheung Ambrose L, Herwald Heiko, Foster Simon, Medina Eva

Abstract excerpt

Host genetic variations play a significant role in conferring predisposition to infection. In this study, we examined the immune mechanisms underlying the host genetic predisposition to severe Staphylococcus aureus infection in different mouse strains. Whereas C57BL/6 mice were the most resistant in terms of control of bacterial growth and survival, A/J, DBA/2, and BALB/c mice were highly susceptible and...

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Identifiers

PMID: 18974303
DOI: 10.2353/ajpath.2008.080337
PMCID: PMC2626378

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MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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