Article

Optimization of a Fresh Fecal Intraperitoneal Injection Sepsis Model and Its Divergent Dynamics from Cecal Ligation and Puncture in Mice

2026-04-02

Abstract excerpt

<title>Abstract</title> <p>Background Sepsis remains a critical challenge in intensive care, necessitating reliable animal models that accurately mimic human pathophysiological responses. While cecal ligation and puncture (CLP) is widely considered the gold standard, its inherent variability often limits reproducibility. This study aimed to optimize a fecal intraperitoneal injection (FIP) murine model by evaluat...

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Literature Corpus work: 921618e6-afad-5abe-b8aa-47bf61bfc8ae
DOI: 10.21203/rs.3.rs-9124307/v1

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