Article
Constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins.
Genome biology - 1 Jan 2001
Jordan I K, Kondrashov F A, Rogozin I B, Tatusov R L, Wolf Y I, Koonin E V
Abstract excerpt
BACKGROUND: Detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. We developed and implemented a simple relative rates test in an attempt to assess the rate constancy of protein evolution and to detect cases of functional diversification between orthologous proteins. The test was performed on clusters of orthologous protein sequences from complete bacterial...
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