Article
Inferring clocks when lacking rocks: the variable rates of molecular evolution in bacteria.
Biology direct - 29 Sept 2009
Kuo Chih-Horng, Ochman Howard
Abstract excerpt
BACKGROUND: Because bacteria do not have a robust fossil record, attempts to infer the timing of events in their evolutionary history requires comparisons of molecular sequences. This use of molecular clocks is based on the assumptions that substitution rates for homologous genes or sites are fairly constant through time and across taxa. Violation of these conditions can lead to erroneous inferences and result in...
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